A Secret Weapon For https://www.ceesdekker.net
A Secret Weapon For https://www.ceesdekker.net
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Employing solitary-molecule optical and AFM imaging and force-spectroscopy procedures, we search for to unravel the mechanistic elements of the structure and dynamics of chromosomes. Our investigate passions consist of:
Our group experiments bacterial mobile division which is aiming to constitute a ‘bottom up biology’ in artificial cells that could autonomously divide. Our principal interest lies in mobile division, chromatin construction, and spatial Manage.
Multicolor imaging of your bacterial nucleoid and mobile division proteins with blue, orange, and around-infrared fluorescent proteins
Our work was rapidly followed up by Other individuals, most notably by Phaedon Avouris and colleagues at IBM, who in October 1998 printed their results on transistors made out of solitary- and multi-walled carbon nanotubes in Utilized Physics Letters.
This yielded a breakthrough. In just just a few months, we were capable to measure transportation through somebody single-walled carbon nanotube. Dependant on minimal-temperature experiments by a superb PhD college student in my team, Sander Tans (now a valued colleague and professor at Delft University of Know-how with the Lively study lab at AMOLF in Amsterdam), we confirmed that carbon nanotubes were real quantum wires with pretty extended (micrometres) Digital coherence lengths — confirming theoretical predictions of metallic behaviour.
Experimental section diagram of negatively supercoiled DNA measured by magnetic tweezers and fluorescence,
What distinguishes biology from chemistry is the fact that these factors collectively make up a dwelling technique. The secret of explained life, I feel, lies in the interactions, the interplay of Those people molecules. The large dilemma in regards to the origin of life remains to be unanswered. How did we ever evolve from basic molecules into your incredibly elaborate techniques we see now? We have no idea. I would like to operate on These types of huge, open up questions.’
2011, initially in vitro measurements of transportation across an individual biomimetic nuclear pore sophisticated; advancement of multiplexed magnetic tweezers for kilo-molecule experiments; and settled the mechanism of homology recognition in DNA homologous recombination
What if, in lieu of employing standard top rated-down silicon electronics, transistors could possibly be built from The underside up making use of one natural molecules given that the switching aspects? This concept, which grew to become The premise of right now’s industry of molecular electronics, 1st emerged in the seventies.
It was through this period that Dekker completed investigation on magnetic spin devices and on sounds in superconductors and semiconductors.
In 1993 he was appointed as Associate https://www.ceesdekker.net Professor at Delft College of Technologies. While in the mid-nineteen nineties Dekker and his group reached success with the discovery on the Digital properties of carbon nanotubes, the initial solitary-molecule transistor and other nanoscience.
‘That problems the synthetic cell, as Element of the Dutch BaSyC initiative. Craig Venter looked top rated-down in These times and discovered about five hundred genes that happen to be minimally needed for the performing cell. We wish to appear bottom-up: how can we shift from a number of molecules to an entire biological program?
Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of just one wire bridging two electrodes
Supercoiling-dependent DNA binding: quantitative modeling and programs to bulk and single-molecule experiments